{"id":2151,"date":"2023-09-09T12:00:00","date_gmt":"2023-09-09T05:00:00","guid":{"rendered":"https:\/\/khoatritruong.com\/?p=2151"},"modified":"2024-07-23T22:07:30","modified_gmt":"2024-07-23T15:07:30","slug":"viem-khop-dang-thap-co-lay-lan-khong","status":"publish","type":"post","link":"https:\/\/khoatritruong.com\/index.php\/2023\/09\/09\/viem-khop-dang-thap-co-lay-lan-khong\/","title":{"rendered":"Vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p c\u00f3 l\u00e2y lan kh\u00f4ng?"},"content":{"rendered":"<span class=\"rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">\u23f3Th\u1eddi gian \u0111\u1ecdc: <\/span> <span class=\"rt-time\">5<\/span> <span class=\"rt-label rt-postfix\">ph\u00fat<\/span><\/span>\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2151\" class=\"elementor elementor-2151\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8d325e1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8d325e1\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c6cad29\" data-id=\"c6cad29\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-cc5a9c6 elementor-widget elementor-widget-text-editor\" data-id=\"cc5a9c6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.16.0 - 14-09-2023 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>M\u1ed9t th\u1eafc m\u1eafc th\u01b0\u1eddng g\u1eb7p c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh m\u1edbi \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p: t\u00f4i c\u00f3 l\u00e2y b\u1ec7nh n\u00e0y cho ng\u01b0\u1eddi th\u00e2n gia \u0111\u00ecnh kh\u00f4ng? T\u00f4i m\u1eafc b\u1ec7nh th\u00ec con t\u00f4i c\u00f3 b\u1ecb b\u1ec7nh kh\u00f4ng (t\u1ee9c c\u00f3 di truy\u1ec1n kh\u00f4ng)?&nbsp;<span style=\"font-style: inherit; font-weight: inherit; background-color: var(--ast-global-color-4); color: var(--ast-global-color-3);\">C\u00e2u tr\u1ea3 l\u1eddi ng\u1eafn g\u1ecdn: Vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p kh\u00f4ng l\u00e2y nh\u01b0 b\u1ec7nh truy\u1ec1n nhi\u1ec5m, nh\u01b0ng n\u1ebfu b\u1ed1 m\u1eb9 m\u1eafc b\u1ec7nh th\u00ec t\u0103ng nguy c\u01a1 con b\u1ecb b\u1ec7nh.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-56906ad elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"56906ad\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b48af05\" data-id=\"b48af05\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-cc2d32c elementor-widget elementor-widget-text-editor\" data-id=\"cc2d32c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Tr\u01b0\u1edbc khi \u0111i v\u00e0o c\u00e2u tr\u1ea3 l\u1eddi c\u1ee5 th\u1ec3, ch\u00fang ta s\u1ebd c\u1ea7n t\u00ecm hi\u1ec3u c\u01a1 ch\u1ebf n\u00e0o g\u00e2y ra vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p (VKDT)?<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-772e169 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"772e169\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8ba1d86\" data-id=\"8ba1d86\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5daa8d3 elementor-widget elementor-widget-heading\" data-id=\"5daa8d3\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.16.0 - 14-09-2023 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-default\">B\u1ec7nh sinh vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-69923f2 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"69923f2\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6d1a481\" data-id=\"6d1a481\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-33e820b elementor-widget elementor-widget-heading\" data-id=\"33e820b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">C\u00fa \u0111\u00e1nh th\u1ee9 nh\u1ea5t<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e7c2585 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e7c2585\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8cf71dc\" data-id=\"8cf71dc\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5eca87a elementor-widget elementor-widget-image\" data-id=\"5eca87a\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.16.0 - 14-09-2023 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"449\" src=\"https:\/\/khoatritruong.com\/wp-content\/uploads\/2023\/09\/Immunology-of-rheumatoid-arthritis-1024x449.png\" class=\"attachment-large size-large wp-image-2168\" alt=\"Immunology of rheumatoid arthritis\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3cf4965 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3cf4965\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e822871\" data-id=\"e822871\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-94a7bd3 elementor-widget elementor-widget-text-editor\" data-id=\"94a7bd3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tCon \u0111\u01b0\u1eddng d\u1eabn t\u1edbi VKDT c\u0169ng l\u1eaft l\u00e9o v\u00e0 hi\u1ec3m tr\u1edf nh\u01b0 con \u0111\u01b0\u1eddng t\u01a1 l\u1ee5a, l\u00e0 t\u1ed5ng h\u00f2a nhi\u1ec1u y\u1ebfu t\u1ed1 gen v\u00e0 m\u00f4i tr\u01b0\u1eddng.\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-49d5b87 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"49d5b87\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-9abf926\" data-id=\"9abf926\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-766ff1a elementor-widget elementor-widget-text-editor\" data-id=\"766ff1a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tVKDT kh\u1edfi ngu\u1ed3n t\u1eeb nhi\u1ec1u n\u0103m tr\u01b0\u1edbc khi tri\u1ec7u ch\u1ee9ng \u0111\u1ea7u ti\u00ean xu\u1ea5t hi\u1ec7n. Kh\u1edfi ph\u00e1t li\u00ean quan nhi\u1ec1u gen c\u00f3 th\u1ec3 sinh kh\u00e1ng th\u1ec3 g\u00e2y b\u1ec7nh g\u1eafn v\u1edbi c\u00e1c protein b\u1ecb bi\u1ebfn \u0111\u1ed5i, ph\u00e1 v\u1ee1 dung n\u1ea1p mi\u1ec5n d\u1ecbch v\u00e0 t\u1ea1o ph\u1ea3n \u1ee9ng t\u1ef1 mi\u1ec5n kh\u00f4ng tri\u1ec7u ch\u1ee9ng (\u201cc\u00fa \u0111\u00e1nh th\u1ee9 nh\u1ea5t\u201d).\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9a1022d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9a1022d\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c032a05\" data-id=\"c032a05\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ae49665 elementor-widget elementor-widget-text-editor\" data-id=\"ae49665\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tPha \u0111\u1ea7u ti\u00ean n\u00e0y \u0111\u01b0\u1ee3c \u0111\u00e1nh d\u1ea5u ch\u1ee7 y\u1ebfu v\u1edbi stress m\u00f4i tr\u01b0\u1eddng th\u00f4ng qua ph\u01a1i nhi\u1ec5m ch\u1ea5t \u0111\u1ed9c h\u1ea1i ho\u1eb7c k\u00edch ho\u1ea1t mi\u1ec5n d\u1ecbch b\u1ea9m sinh. Ch\u00fang bao g\u1ed3m kh\u00f3i thu\u1ed1c l\u00e1, s\u1ea3n ph\u1ea9m c\u1ee7a vi khu\u1ea9n, virus, nhi\u1ec5m tr\u00f9ng khu tr\u00fa tr\u00ean ni\u00eam m\u1ea1c v\u00e0 c\u00e1c k\u00edch th\u00edch m\u00f4i tr\u01b0\u1eddng kh\u00e1c.\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c9558d8 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c9558d8\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-76c3722\" data-id=\"76c3722\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3125621 elementor-widget elementor-widget-text-editor\" data-id=\"3125621\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tNh\u1eefng stress n\u00e0y g\u00e2y t\u0103ng ho\u1ea1t c\u00e1c enzyme l\u00e0m bi\u1ebfn \u0111\u1ed5i peptide b\u00ecnh th\u01b0\u1eddng; th\u01b0\u1eddng g\u1eb7p nh\u1ea5t l\u00e0 con \u0111\u01b0\u1eddng chuy\u1ec3n arginine th\u00e0nh citrulline v\u00e0 c\u00f3 th\u1ec3 qua nh\u1eefng con \u0111\u01b0\u1eddng kh\u00e1c nh\u01b0 carbamyl h\u00f3a v.v. Qu\u00e1 tr\u00ecnh bi\u1ebfn \u0111\u1ed5i protein v\u1eabn c\u00f3 x\u1ea3y ra \u1edf ng\u01b0\u1eddi kh\u1ecfe m\u1ea1nh v\u00e0 t\u1ef1 gi\u1edbi h\u1ea1n, kh\u00f4ng c\u00f3 t\u00e1c \u0111\u1ed9ng g\u00e2y b\u1ec7nh. \t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ddc51a5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ddc51a5\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e43f481\" data-id=\"e43f481\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ac11bc1 elementor-widget elementor-widget-text-editor\" data-id=\"ac11bc1\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tNh\u01b0ng v\u1edbi nh\u1eefng ng\u01b0\u1eddi mang gen nguy c\u01a1\u2014\u0111\u00e1ng ch\u00fa \u00fd nh\u1ea5t l\u00e0 gen MHC nh\u00f3m II\u2014peptide b\u1ecb citrulline h\u00f3a s\u1ebd g\u1eafn ch\u1eb7t ch\u1ebd v\u1edbi v\u00f9ng g\u1eafn kh\u00e1ng nguy\u00ean, tr\u00ecnh di\u1ec7n v\u1edbi t\u1ebf b\u00e0o T hi\u1ec7u qu\u1ea3 h\u01a1n protein ch\u01b0a b\u1ecb bi\u1ebfn \u0111\u1ed5i. V\u00ec t\u1ebf b\u00e0o T ch\u01b0a ti\u1ebfp x\u00fac v\u1edbi peptide bi\u1ebfn \u0111\u1ed5i n\u00e0y trong qu\u00e1 tr\u00ecnh ph\u00e1t tri\u1ec3n n\u00ean khi t\u1ebf b\u00e0o T t\u1eeb tuy\u1ebfn \u1ee9c ti\u1ebfp x\u00fac peptide bi\u1ebfn \u0111\u1ed5i s\u1ebd t\u1ea1o \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch \u0111\u00e1p \u1ee9ng ch\u1ed1ng l\u1ea1i c\u00e1c y\u1ebfu t\u1ed1 quy\u1ebft \u0111\u1ecbnh tr\u00ean kh\u00e1ng nguy\u00ean n\u00e0y (g\u1ecdi l\u00e0 epitope).\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-62b2fa8 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"62b2fa8\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-57a08d3\" data-id=\"57a08d3\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8ede073 elementor-widget elementor-widget-text-editor\" data-id=\"8ede073\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tQu\u00e1 tr\u00ecnh ti\u1ebfp x\u00fac th\u01b0\u1eddng x\u1ea3y ra tr\u00ean b\u1ec1 m\u1eb7t ni\u00eam m\u1ea1c \u1edf ph\u1ed5i, ru\u1ed9t v\u00e0 khoang mi\u1ec7ng, th\u01b0\u1eddng nh\u1ea5t t\u1ea1o ra kh\u00e1ng th\u1ec3 ch\u1ed1ng l\u1ea1i peptide \u0111\u01b0\u1ee3c citrulline h\u00f3a (ACPA, anti-citrullinated protein antibody ho\u1eb7c c\u00f2n g\u1ecdi l\u00e0 anti CCP, anti cyclic citrullinated protein). Anti CCP ch\u1ed1ng l\u1ea1i nhi\u1ec1u protein nh\u01b0 fibronectin, vimentin, histone, \u03b1-enolase v.v.\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-785dd7d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"785dd7d\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2e48a8c\" data-id=\"2e48a8c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2f24f7e elementor-widget elementor-widget-heading\" data-id=\"2f24f7e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">C\u00fa \u0111\u00e1nh th\u1ee9 hai<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-86e7f8d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"86e7f8d\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5a6f73e\" data-id=\"5a6f73e\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e6243e6 elementor-widget elementor-widget-text-editor\" data-id=\"e6243e6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tQua nhi\u1ec1u n\u0103m, l\u01b0\u1ee3ng anti CCP ch\u1ed1ng l\u1ea1i \u0111a d\u1ea1ng protein t\u0103ng l\u00ean nhi\u1ec1u l\u1ea7n. Tuy nhi\u00ean, anti CPP t\u1ef1 b\u1ea3n th\u00e2n kh\u00f4ng \u0111\u1ee7 g\u00e2y vi\u00eam m\u00e0ng ho\u1ea1t d\u1ecbch, v\u00e0 c\u1ea7n \u201cc\u00fa \u0111\u00e1nh th\u1ee9 hai\u201d. Anti CCP ti\u1ebfp x\u00fac th\u1ee5 th\u1ec3 Fc tr\u00ean m\u00e0ng ho\u1ea1t d\u1ecbch, gi\u1ea3i ph\u00f3ng ch\u1ea5t trung gian gi\u00e3n m\u1ea1ch, l\u00e0m anti CCP \u0111i v\u00e0o kh\u1edbp nhi\u1ec1u h\u01a1n.\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-06b8261 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"06b8261\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a370a88\" data-id=\"a370a88\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e91ebde elementor-widget elementor-widget-text-editor\" data-id=\"e91ebde\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>M\u1ed9t khi \u0111\u00e3 v\u00e0o kh\u1edbp, n\u1ebfu anti CCP ti\u1ebfp x\u00fac kh\u00e1ng nguy\u00ean th\u00ec ch\u00fang c\u00f3 th\u1ec3 c\u1ed1 \u0111\u1ecbnh b\u1ed5 th\u1ec3, kh\u1edfi \u0111\u1ed9ng m\u1ed9t ph\u1ea3n \u1ee9ng d\u00e2y chuy\u1ec1n, huy \u0111\u1ed9ng t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch b\u1ea9m sinh v\u00e0 \u0111\u00e1p \u1ee9ng, s\u1ea3n xu\u1ea5t th\u00eam cytokine v\u00e0 chemokine, ho\u1ea1t h\u00f3a t\u1ebf b\u00e0o ho\u1ea1t d\u1ecbch gi\u1ed1ng nguy\u00ean b\u00e0o s\u1ee3i v\u00e0 \u0111\u1ea1i th\u1ef1c b\u00e0o. \u0110\u00e2y l\u00e0 \u201cgi\u1ecdt n\u01b0\u1edbc tr\u00e0n ly\u201d d\u1eabn \u0111\u1ebfn vi\u00eam kh\u1edbp tr\u00ean l\u00e2m s\u00e0ng.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1b7cc6d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1b7cc6d\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8dfa9cf\" data-id=\"8dfa9cf\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-09f72ab elementor-widget elementor-widget-text-editor\" data-id=\"09f72ab\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>H\u00e0ng lo\u1ea1t y\u1ebfu t\u1ed1 di truy\u1ec1n c\u01b0\u1eddng \u0111\u1ea1i \u0111\u00e1p \u1ee9ng v\u1edbi protein b\u1ecb bi\u1ebfn \u0111\u1ed5i, t\u1ea1o t\u1ef1 mi\u1ec5n ch\u1ed1ng l\u1ea1i protein b\u00ecnh th\u01b0\u1eddng th\u00f4ng qua lan truy\u1ec1n epitope (v\u00ed nh\u01b0 ch\u1ee7 n\u1ee3 si\u1ebft th\u1eb1ng anh n\u1ee3 n\u1ea7n l\u1eabn th\u1eb1ng em v\u00f4 t\u1ed9i v\u00ec nh\u00ecn hao hao th\u1eb1ng anh) ho\u1eb7c vi\u00eam m\u00e0ng ho\u1ea1t d\u1ecbch t\u1ea1i ch\u1ed7. \u0110a h\u00ecnh c\u1ee7a gen m\u00e3 h\u00f3a t\u00edn hi\u1ec7u t\u1ebf b\u00e0o T (PTPN22), \u0111a h\u00ecnh c\u1ee7a promoter gen cytokin t\u0103ng c\u01b0\u1eddng th\u00eam ph\u1ea3n \u1ee9ng n\u00e0y. Ngo\u00e0i ra, thay \u0111\u1ed5i ngo\u1ea1i di truy\u1ec1n (epigenetic) nh\u01b0 methyl h\u00f3a DNA, microRNA, thay \u0111\u1ed5i histone c\u0169ng tham gia l\u00e0m \u201ct\u00f2ng ph\u1ea1m\u201d.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3b870e3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3b870e3\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-710c818\" data-id=\"710c818\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-441ce23 elementor-widget elementor-widget-text-editor\" data-id=\"441ce23\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tM\u1eb7c d\u00f9 c\u01a1 ch\u1ebf kh\u00e1ng vi\u00eam c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c l\u00f4i ra ch\u1ed1ng \u0111\u1ecbch, nh\u01b0ng ch\u00fang kh\u00f4ng \u0111\u1ee7 \u0111\u1ec3 d\u1eadp t\u1eaft qu\u00e1 tr\u00ecnh vi\u00eam v\u00e0 ph\u00e1 h\u1ee7y. M\u1ed9t v\u00e0i ng\u01b0\u1eddi s\u1ebd b\u1ec7nh ph\u1ee5 thu\u1ed9c cytokine, v\u00e0i ng\u01b0\u1eddi l\u1ea1i ph\u1ee5 thu\u1ed9c t\u1ebf b\u00e0o B v\u00e0 v\u00e0i ng\u01b0\u1eddi kh\u00e1c ph\u1ee5 thu\u1ed9c t\u1ebf b\u00e0o T, th\u1eadm ch\u00ed ph\u1ed1i h\u1ee3p ph\u1ee9c t\u1ea1p nhi\u1ec1u c\u01a1 ch\u1ebf. \u0110i\u1ec1u n\u00e0y g\u1ee3i \u00fd VKDT c\u00f3 th\u1ec3 l\u00e0 m\u1ed9t ph\u1ed5 c\u00e1c r\u1ed1i lo\u1ea1n kh\u00e1c nhau theo t\u1eebng b\u1ec7nh nh\u00e2n, ph\u1ee5 thu\u1ed9c v\u00e0o d\u1ea5u \u1ea5n di truy\u1ec1n v\u00e0 y\u1ebfu t\u1ed1 k\u00edch ph\u00e1t m\u00f4i tr\u01b0\u1eddng.\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-97e375a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"97e375a\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b2adb8c\" data-id=\"b2adb8c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3c1ed57 elementor-widget elementor-widget-heading\" data-id=\"3c1ed57\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p c\u00f3 l\u00e2y kh\u00f4ng?<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8b4dfba elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8b4dfba\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b4b95e0\" data-id=\"b4b95e0\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5bcc201 elementor-widget elementor-widget-text-editor\" data-id=\"5bcc201\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tQuay l\u1ea1i c\u00e2u h\u1ecfi ban \u0111\u1ea7u. M\u1eb7c d\u00f9 b\u1ec7nh sinh c\u00f3 th\u1ec3 li\u00ean quan nhi\u1ec5m tr\u00f9ng t\u1ea1i ch\u1ed7 ni\u00eam m\u1ea1c nh\u01b0ng r\u00f5 r\u00e0ng VKDT kh\u00f4ng th\u1ec3 l\u00e2y lan gi\u1eefa ng\u01b0\u1eddi v\u1edbi ng\u01b0\u1eddi nh\u01b0 b\u1ec7nh truy\u1ec1n nhi\u1ec5m, v\u00ec \u0111\u00e2y l\u00e0 b\u1ec7nh \u0111a y\u1ebfu t\u1ed1 k\u1ebft h\u1ee3p di truy\u1ec1n v\u00e0 m\u00f4i tr\u01b0\u1eddng. V\u1eady VKDT c\u00f3 di truy\u1ec1n sang \u0111\u1eddi con?\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a153707 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a153707\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-68c7212\" data-id=\"68c7212\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7659103 elementor-widget elementor-widget-text-editor\" data-id=\"7659103\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tC\u00e1c nghi\u00ean c\u1ee9u s\u1ed5 b\u1ed9 tr\u00ean d\u00e2n s\u1ed1 Iceland, Th\u1ee5y \u0110i\u1ec3n, \u0110an M\u1ea1ch cho th\u1ea5y ng\u01b0\u1eddi th\u00e2n h\u00e0ng 1 c\u00f3 th\u1ec3 t\u0103ng nguy c\u01a1 m\u1eafc VKDT kho\u1ea3ng 4 l\u1ea7n v\u00e0 ng\u01b0\u1eddi th\u00e2n h\u00e0ng 2 kho\u1ea3ng 2 l\u1ea7n.\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f6bf41c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f6bf41c\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-b28f4ba\" data-id=\"b28f4ba\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b3d564d elementor-widget elementor-widget-accordion\" data-id=\"b3d564d\" data-element_type=\"widget\" data-widget_type=\"accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.16.0 - 14-09-2023 *\/\n.elementor-accordion{text-align:left}.elementor-accordion .elementor-accordion-item{border:1px solid #d5d8dc}.elementor-accordion .elementor-accordion-item+.elementor-accordion-item{border-top:none}.elementor-accordion .elementor-tab-title{margin:0;padding:15px 20px;font-weight:700;line-height:1;cursor:pointer;outline:none}.elementor-accordion .elementor-tab-title .elementor-accordion-icon{display:inline-block;width:1.5em}.elementor-accordion .elementor-tab-title .elementor-accordion-icon svg{width:1em;height:1em}.elementor-accordion .elementor-tab-title .elementor-accordion-icon.elementor-accordion-icon-right{float:right;text-align:right}.elementor-accordion .elementor-tab-title .elementor-accordion-icon.elementor-accordion-icon-left{float:left;text-align:left}.elementor-accordion .elementor-tab-title .elementor-accordion-icon .elementor-accordion-icon-closed{display:block}.elementor-accordion .elementor-tab-title .elementor-accordion-icon .elementor-accordion-icon-opened,.elementor-accordion .elementor-tab-title.elementor-active .elementor-accordion-icon-closed{display:none}.elementor-accordion .elementor-tab-title.elementor-active .elementor-accordion-icon-opened{display:block}.elementor-accordion .elementor-tab-content{display:none;padding:15px 20px;border-top:1px solid #d5d8dc}@media (max-width:767px){.elementor-accordion .elementor-tab-title{padding:12px 15px}.elementor-accordion .elementor-tab-title .elementor-accordion-icon{width:1.2em}.elementor-accordion .elementor-tab-content{padding:7px 15px}}.e-con-inner>.elementor-widget-accordion,.e-con>.elementor-widget-accordion{width:var(--container-widget-width);--flex-grow:var(--container-widget-flex-grow)}<\/style>\t\t<div class=\"elementor-accordion\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1881\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1881\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-plus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-minus\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">H\u1ec7 s\u1ed1 di truy\u1ec1n l\u00e0 g\u00ec?<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-1881\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1881\"><p>H\u1ec7 s\u1ed1 di truy\u1ec1n (heritability) l\u00e0 m\u1ed9t ch\u1ec9 s\u1ed1 th\u1ed1ng k\u00ea, ch\u1ec9 m\u1ee9c \u0111\u1ed9 di truy\u1ec1n cao hay th\u1ea5p c\u1ee7a m\u1ed9t t\u00ednh tr\u1ea1ng.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-ca9592e\" data-id=\"ca9592e\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a1631db elementor-widget elementor-widget-text-editor\" data-id=\"a1631db\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tN\u0103m 1970, Lawrence l\u1ea7n \u0111\u1ea7u \u01b0\u1edbc t\u00ednh h\u1ec7 s\u1ed1 di truy\u1ec1n c\u1ee7a VKDT v\u00e0o kho\u1ea3ng 60 \u2013 70% cho tr\u01b0\u1eddng h\u1ee3p huy\u1ebft thanh d\u01b0\u01a1ng t\u00ednh. Nh\u01b0ng do Lawrence gi\u1ea3 \u0111\u1ecbnh t\u00ednh gia \u0111\u00ecnh ho\u00e0n to\u00e0n do t\u00e1c \u0111\u1ed9ng gen, m\u1ed9t nh\u00f3m t\u00e1c gi\u1ea3 kh\u00e1c s\u1eed d\u1ee5ng d\u1eef li\u1ec7u s\u1ed5 b\u1ed9 Th\u1ee5y \u0111i\u1ec3n (2016) \u01b0\u1edbc t\u00ednh h\u1ec7 s\u1ed1 di truy\u1ec1n ch\u1ec9 40%..\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0bbef16 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0bbef16\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d7d6bf5\" data-id=\"d7d6bf5\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-58bd516 elementor-widget elementor-widget-text-editor\" data-id=\"58bd516\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tM\u1ed9t ph\u01b0\u01a1ng ph\u00e1p kinh \u0111i\u1ec3n \u0111\u1ec3 t\u00e1ch bi\u1ec7t t\u00e1c \u0111\u1ed9ng m\u00f4i tr\u01b0\u1eddng v\u00e0 t\u00e1c \u0111\u1ed9ng di truy\u1ec1n l\u00e0 nghi\u00ean c\u1ee9u ng\u01b0\u1eddi sinh \u0111\u00f4i. MacGregor v\u00e0 c\u1ed9ng s\u1ef1 th\u1ef1c hi\u1ec7n nghi\u00ean c\u1ee9u cho th\u1ea5y t\u1ec9 l\u1ec7 t\u01b0\u01a1ng h\u1ee3p l\u00e0 12 \u2013 15% tr\u00ean c\u1eb7p sinh \u0111\u00f4i c\u00f9ng tr\u1ee9ng, 2 \u2013 5% tr\u00ean c\u1eb7p sinh \u0111\u00f4i kh\u00e1c tr\u1ee9ng. T\u1ec9 l\u1ec7 n\u00e0y kh\u00f4ng cao cho th\u1ea5y y\u1ebfu t\u1ed1 m\u00f4i tr\u01b0\u1eddng ho\u1eb7c epigenetic c\u00f3 th\u1ec3 c\u0169ng quan tr\u1ecdng t\u01b0\u01a1ng \u0111\u01b0\u01a1ng y\u1ebfu t\u1ed1 di truy\u1ec1n.\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6dd52b7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6dd52b7\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ff95579\" data-id=\"ff95579\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9a63bcc elementor-widget elementor-widget-text-editor\" data-id=\"9a63bcc\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>\u0110\u1ed1i v\u1edbi m\u1ed1i li\u00ean quan gi\u1eefa di truy\u1ec1n v\u00e0 huy\u1ebft thanh d\u01b0\u01a1ng t\u00ednh (anti CCP d\u01b0\u01a1ng), m\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u cho th\u1ea5y OR cho VKDT huy\u1ebft thanh d\u01b0\u01a1ng l\u00e0 3,95 (KTC 95%: 3,72 \u2013 4,19) (cho ng\u01b0\u1eddi th\u00e2n h\u00e0ng 1) so v\u1edbi OR cho VKDT huy\u1ebft thanh \u00e2m l\u00e0 2,47 (2,24 \u2013 2,72). T\u1eeb \u0111\u00f3 t\u00ednh \u0111\u01b0\u1ee3c h\u1ec7 s\u1ed1 di truy\u1ec1n cho VKDT huy\u1ebft thanh d\u01b0\u01a1ng l\u00e0 40 \u2013 50% v\u00e0 huy\u1ebft thanh \u00e2m l\u00e0 20 \u2013 30%.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-67d3360 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"67d3360\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-eae8322\" data-id=\"eae8322\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-41bc489 elementor-widget elementor-widget-heading\" data-id=\"41bc489\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">L\u1eddi k\u1ebft<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-412d40c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"412d40c\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b2b1376\" data-id=\"b2b1376\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a6d8cc1 elementor-widget elementor-widget-text-editor\" data-id=\"a6d8cc1\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tT\u00f3m l\u1ea1i, VKDT kh\u00f4ng l\u00e2y tr\u1ef1c ti\u1ebfp t\u1eeb ng\u01b0\u1eddi sang ng\u01b0\u1eddi. Nh\u01b0ng khi c\u00f3 ng\u01b0\u1eddi th\u00e2n m\u1eafc VKDT th\u00ec nguy c\u01a1 b\u1ecb VKDT t\u0103ng 2 \u2013 4 l\u1ea7n, h\u1ec7 s\u1ed1 di truy\u1ec1n (t\u1ee9c m\u1ee9c \u0111\u1ed9 cha m\u1eb9 di truy\u1ec1n l\u1ea1i b\u1ec7nh sang con) kho\u1ea3ng 40%. N\u1ebfu VKDT huy\u1ebft thanh d\u01b0\u01a1ng th\u00ec kh\u1ea3 n\u0103ng di truy\u1ec1n cao h\u01a1n huy\u1ebft thanh \u00e2m.\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5a481fb elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5a481fb\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c5d8390\" data-id=\"c5d8390\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4e096f3 elementor-widget elementor-widget-heading\" data-id=\"4e096f3\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-db285a8 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"db285a8\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0f9e833\" data-id=\"0f9e833\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-02564ed elementor-widget elementor-widget-text-editor\" data-id=\"02564ed\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ol>\n \t<li>Firestein GS. Etiology of rheumatoid arthritis. In: Firestein GS, Budd RC, Gabriel SE, Koretzky GA, McInnes IB, O&#8217;Dell JR, eds. Firestein &amp; Kelly&#8217;s Textbook of Rheumatology. 11th ed. Elsevier; :1181-1199.<\/li>\n \t<li><a href=\"https:\/\/doi.org\/10.1038\/nrrheum.2016.52\">Frisell T, Saevarsdottir S, Askling J. Family history of rheumatoid arthritis: an old concept with new developments. Nat Rev Rheumatol. 2016;12(6):335-343.<\/a><\/li>\n \t<li><a href=\"https:\/\/doi.org\/10.1002\/1529-0131(200110)44:10%3C2247::AID-ART387%3E3.0.CO;2-Y\">Grant SF, Thorleifsson G, Frigge ML, et al. The inheritance of rheumatoid arthritis in Iceland. Arthritis Rheum. 2001;44(10):2247-2254.<\/a><\/li>\n \t<li><a href=\"https:\/\/doi.org\/10.1136\/ard.29.4.357\">Lawrence JS. Heberden Oration, 1969. Rheumatoid arthritis&#8211;nature or nurture?. Ann Rheum Dis. 1970;29(4):357-379.<\/a><\/li>\n \t<li><a href=\"https:\/\/doi.org\/10.1002\/1529-0131(200001)43:1%3C30::AID-ANR5%3E3.0.CO;2-B\">MacGregor AJ, Snieder H, Rigby AS, et al. Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins. Arthritis Rheum. 2000;43(1):30-37.<\/a><\/li>\n \t<li><a href=\"https:\/\/doi.org\/10.1002\/art.38097\">Frisell T, Holmqvist M, K\u00e4llberg H, Klareskog L, Alfredsson L, Askling J. Familial risks and heritability of rheumatoid arthritis: role of rheumatoid factor\/anti-citrullinated protein antibody status, number and type of affected relatives, sex, and age. Arthritis Rheum. 2013;65(11):2773-2782.<\/a><\/li>\n \t<li><a href=\"https:\/\/doi.org\/10.1136\/annrheumdis-2014-206133\">Frisell T, Hellgren K, Alfredsson L, Raychaudhuri S, Klareskog L, Askling J. Familial aggregation of arthritis-related diseases in seropositive and seronegative rheumatoid arthritis: a register-based case-control study in Sweden. Ann Rheum Dis. 2016;75(1):183-189.<\/a><\/li>\n<li><a href=\"doi:10.1038\/s41590-020-00816-x\">Weyand CM, Goronzy JJ. The immunology of rheumatoid arthritis. Nat Immunol. 2021;22(1):10-18.<\/a><\/li>\n<\/ol>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p><span class=\"rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">\u23f3Th\u1eddi gian \u0111\u1ecdc: <\/span> <span class=\"rt-time\">5<\/span> <span class=\"rt-label rt-postfix\">ph\u00fat<\/span><\/span> M\u1ed9t th\u1eafc m\u1eafc th\u01b0\u1eddng g\u1eb7p c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh m\u1edbi \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p: t\u00f4i c\u00f3 l\u00e2y b\u1ec7nh n\u00e0y cho ng\u01b0\u1eddi th\u00e2n gia \u0111\u00ecnh kh\u00f4ng? T\u00f4i m\u1eafc b\u1ec7nh th\u00ec con t\u00f4i c\u00f3 b\u1ecb b\u1ec7nh kh\u00f4ng (t\u1ee9c c\u00f3 di truy\u1ec1n kh\u00f4ng)?&nbsp;C\u00e2u tr\u1ea3 l\u1eddi ng\u1eafn g\u1ecdn: Vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p kh\u00f4ng l\u00e2y nh\u01b0 b\u1ec7nh truy\u1ec1n &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"\" href=\"https:\/\/khoatritruong.com\/index.php\/2023\/09\/09\/viem-khop-dang-thap-co-lay-lan-khong\/\"> <span class=\"screen-reader-text\">Vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p c\u00f3 l\u00e2y lan kh\u00f4ng?<\/span> Read More &raquo;<\/a><\/p>\n","protected":false},"author":1,"featured_media":2185,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","footnotes":""},"categories":[16],"tags":[26,15],"class_list":["post-2151","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-viem-khop-dang-thap","tag-danh-cho-nhan-vien-y-te","tag-viem-khop-dang-thap"],"aioseo_notices":[],"rttpg_featured_image_url":{"full":["https:\/\/khoatritruong.com\/wp-content\/uploads\/2023\/09\/Is-rheumatoid-arthritis-transmitable.png",1920,1080,false],"landscape":["https:\/\/khoatritruong.com\/wp-content\/uploads\/2023\/09\/Is-rheumatoid-arthritis-transmitable.png",1920,1080,false],"portraits":["https:\/\/khoatritruong.com\/wp-content\/uploads\/2023\/09\/Is-rheumatoid-arthritis-transmitable.png",1920,1080,false],"thumbnail":["https:\/\/khoatritruong.com\/wp-content\/uploads\/2023\/09\/Is-rheumatoid-arthritis-transmitable-150x150.png",150,150,true],"medium":["https:\/\/khoatritruong.com\/wp-content\/uploads\/2023\/09\/Is-rheumatoid-arthritis-transmitable-300x169.png",300,169,true],"large":["https:\/\/khoatritruong.com\/wp-content\/uploads\/2023\/09\/Is-rheumatoid-arthritis-transmitable-1024x576.png",1024,576,true],"1536x1536":["https:\/\/khoatritruong.com\/wp-content\/uploads\/2023\/09\/Is-rheumatoid-arthritis-transmitable-1536x864.png",1536,864,true],"2048x2048":["https:\/\/khoatritruong.com\/wp-content\/uploads\/2023\/09\/Is-rheumatoid-arthritis-transmitable.png",1920,1080,false]},"rttpg_author":{"display_name":"Tr\u01b0\u01a1ng Tr\u00ed Khoa","author_link":"https:\/\/khoatritruong.com\/index.php\/author\/khoatritruong-com\/"},"rttpg_comment":29,"rttpg_category":"<a href=\"https:\/\/khoatritruong.com\/index.php\/category\/viem-khop-dang-thap\/\" rel=\"category tag\">Vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p<\/a>","rttpg_excerpt":"\u23f3Th\u1eddi gian \u0111\u1ecdc: 5 ph\u00fat M\u1ed9t th\u1eafc m\u1eafc th\u01b0\u1eddng g\u1eb7p c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh m\u1edbi \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p: t\u00f4i c\u00f3 l\u00e2y b\u1ec7nh n\u00e0y cho ng\u01b0\u1eddi th\u00e2n gia \u0111\u00ecnh kh\u00f4ng? T\u00f4i m\u1eafc b\u1ec7nh th\u00ec con t\u00f4i c\u00f3 b\u1ecb b\u1ec7nh kh\u00f4ng (t\u1ee9c c\u00f3 di truy\u1ec1n kh\u00f4ng)?&nbsp;C\u00e2u tr\u1ea3 l\u1eddi ng\u1eafn g\u1ecdn: Vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p&hellip;","_links":{"self":[{"href":"https:\/\/khoatritruong.com\/index.php\/wp-json\/wp\/v2\/posts\/2151"}],"collection":[{"href":"https:\/\/khoatritruong.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/khoatritruong.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/khoatritruong.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/khoatritruong.com\/index.php\/wp-json\/wp\/v2\/comments?post=2151"}],"version-history":[{"count":25,"href":"https:\/\/khoatritruong.com\/index.php\/wp-json\/wp\/v2\/posts\/2151\/revisions"}],"predecessor-version":[{"id":2308,"href":"https:\/\/khoatritruong.com\/index.php\/wp-json\/wp\/v2\/posts\/2151\/revisions\/2308"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/khoatritruong.com\/index.php\/wp-json\/wp\/v2\/media\/2185"}],"wp:attachment":[{"href":"https:\/\/khoatritruong.com\/index.php\/wp-json\/wp\/v2\/media?parent=2151"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/khoatritruong.com\/index.php\/wp-json\/wp\/v2\/categories?post=2151"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/khoatritruong.com\/index.php\/wp-json\/wp\/v2\/tags?post=2151"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}